fñaMtmGaharEdlmineFVI[elakGñkFøak;xøÜn QW\LÚvenHRtÚv)anbegáIt
eLIgedayRkúmGñkviTüasa®sþehIy .    RbePTfñaMEdlCYybBaÄb;cM
Ng;XøanGahareday eRbIG½rm:UnEdlRtÚv)anbegáIteLIgtamEbbFmµ
CatienAkñúgRkBHenAeBlEdlvaeBareBjedayGaharenaHRtÚv)aneK
RbkaspSBVpSayfaCafñaMdMbUgbMput  EdlrMlaynUvsmasFatuTm¶n;
mincaM)ac;edaymin

bgá[manplb:HBal;eRKaHfñak;enaHeLIy . fñaMRbePTfµIenHmaneQµaHfa OAP-1*( KWCaCMerIsd
¾gayRsÜl nig suvtßiPaBCagfñaMsRmkTm¶n;EdlkMBuglk;elITIpSarGg;eKøseQµaHfa Xenical Edlf
ñaMRbePTenHvabgá[manplb:HBal;dUcCa eFVI[xUcebHdUg nig bgá[manbBaðastiGarmµN_F¶n;F¶r .
GñkEdlbegáItfñaMRbePTenHKWsa®sþacarüelak esþehVn bøÚm KWCaGñkCMnajxagBüa)alPaBFat;h
YsRbmaNQanmuxeKmYyrUbkñúgBiPBelak mkBIsaklviTüal½y Imperial College London )anniyayfa
fñaM OAP-!*( enHdMeNIrkartamry³kareFVIRtab;tamG½rm:UneBaHevon Oxyntomodulin Edlragka
ybegáIteLIgenAeBlEdlvamanRKb;RKan;lµmedIm,ITTYlTanGahar . kMritG½rm:UnenHk¾mankarekI
neLIgpgEdrcMeBaHmnusSEdlFøab;TTYlkarvHkat;RkBHEdlkñúgenaHRkBHkan;EtrYmtUc ehIybMBg;rM
layGaharRtÚv)anteLIgvij . karvHkat;BitCamanRbsiT§iPaBk¾b:uEnþminEmnminmanhaniP½yenaH
eT dUecñHehIyeTIbelakbøÚm)anRsavRCavrknUvviFIsRmkTm¶n;edaymincaM)ac;eFVIkarvHkat; .
elakniyayfa "´KitfaeyIgGacykRtab;tamkarsRmkTm¶n;d¾KYr[PJak;ep¥IlEdlTTYl)aneCaKC½yCamY
ynwgkarvHkat;RkBHtamry³karpþl;[mnusSnUv viFIBüa)alEdlTajecjmkBIG½rm:UnRkBH . Rbsineb
IGñkGacecosq¶ayBIPaBeRskXøan enaHmðÚbGaharElgCaerOgKYr[cab;GarmµN_eTotehIy" . elak)a
nEføgfa tamry³karpþl;nUvG½rm:Un Oxyntomodulin cMnYn 3 elIkRbcaMéf¶[eTAGñkEdlelIsTm¶n;
nig Fat;RCúl ehIyBYkeK)anRskTm¶n;CamFüm )an 5 lb kñúgeBl 4 s)aþh_ . eRkaymkeTot ela
kk¾begáItG½rm:Un Oxyntomodulin eLIgvijeTACafñaM OAP-!*( EdlGacRtÚv)anpþl;[GñkFat;hYsR
bmaNCaRbcaM éf¶ b¤ RbcaMs)aþh_)aneTotpg . fñaMRbePTenHRtÚv)anENnaM[sÁal;edayRkúmh‘un
plit»sf Pfizer ehIynaeBlbc©úb,nñenHkMBugsßitkñúgdMNak;kalsakl,gsRmab;mnusSenAeLIyeT .
plb:HBal;rbs;fñaMenHRtÚveKBüakrN_famankMrittictYcb:ueNÑaH k¾b:uEnþ OAP-!*( nwgRtÚvq
øgkat;kareFVIetsþ_sakl,geTAelImnusSmuneBlvaQancUlTIpSar enAcenøaH 3 eTA 7 qñaM xagmux
eTot .